Intracytoplasmic Sperm Injection (ICSI) is a specialised form of In Vitro Fertilisation (IVF) that is used primarily for the treatment of severe cases of male-factor infertility. ICSI involves the injection of a single sperm directly into a mature egg. It has different version as PICSI in which the specialized medium contains hyaluronan (HA), which binds sperm that are more likely to have normal DNA and thus allows selection of these bound sperm for injection. By selecting the sperm that are bound to HA and using them for ICSI, the embryologists are preferentially using the better-quality, more mature sperm. Please note that, while this technique using HA is standard practice, it may not be suitable in every case depending on individual circumstances. Please remember anyone can be affected by infertility and while it can be a challenging experience, the good news is that our Akshara Fertility Center specialists can help you explore the options available to achieve your dream of having a baby.